Table 2. In Vitro Cytotoxicity of The Halido Complexes (1–4Cl and 3Br), and fac-[Re(CO)3(bpy)(Cl)] as a Reference Compound, Tested in The Drug-Sensitive Colo205 and Its Resistant Counterpart Colo320 Human Colon Adenocarcinoma Cell Lines, In Addition to The Resistance Factors (RF = IC50(Colo320)/ IC50(Colo205))a.
| IC50 (μM) | Colo205 | Colo320 | RF |
|---|---|---|---|
| 1Cl | 87.24 ± 0.92 | 97.1 ± 1.6 | 1.11 |
| 2Cl | 96.48 ± 0.10 | 99.16 ± 0.25 | 1.03 |
| 3Cl | 66.0 ± 1.7 | 83.03 ± 0.50 | 1.26 |
| 3Br | 62.6 ± 3.7 | 72.66 ± 0.40 | 1.16 |
| 4Cl | 60.2 ± 1.3 | 76.3 ± 2.2 | 1.27 |
| fac-[Re(CO)3(bpy)(Cl)] | 25.2 ± 1.1 | 49.1 ± 1.7 | 1.95 |
| doxorubicin | 0.58 ± 0.06 | 3.13 ± 0.29 | 5.17 |
a
IC50 values of 1–4Aq > 100 μM in both cell lines. {incubation time: 72 h}.