Skip to main content
. 2024 Oct 1;56(10):2145–2161. doi: 10.1038/s12276-024-01289-w

Fig. 5. Intronic APA renders diverse C-terminome features.

Fig. 5

a The histogram displays the distribution of relative positions of the 3’-last exon of intronic APA transcripts to the full-length transcript in the same gene in the pan-cancer dataset. Enriched KEGG pathways corresponding to early or late termination of transcripts are presented. b Comparison of full-length vs. truncated proteins grouped by the relative position of intronic APA events. The gray shaded area denotes the length of truncated proteins that fall within ±10% of the corresponding full-length proteins. c The histogram shows the distribution of intronic APA positions in BRCA and KIRC. d A schematic representation of Pfam domains that are lost by intronic APA and enriched in select KEGG pathways. Yellow boxes where the open reading frames of intronic APA transcripts end are linked to the positions of the truncated proteins in the diagram. e Differential gene expression for select genes enriched in the KEGG pathways shown in (a). The selected genes are color-coded by cancer type where intronic APA events are statistically significant.