Table 1.
Characteristics of Patients with SHD with Favorable Neurologic Outcomes vs. Death or SHD with Unfavorable Neurologic Outcomes.
| Variable |
Total (N = 82) |
SHD with Favorable Neurologic Outcome (N = 35) | Death or SHD with Unfavorable Neurologic Outcome (N = 47) | P value |
|---|---|---|---|---|
| Pre-arrest | ||||
| Age (months) | 0.3[0.1,3.6] | 0.2[0.0,11.5] | 0.3[0.1,3.2] | 0.70 |
| Race (white) | 54(65.9) | 23(42.6) | 31(57.4) | 0.98 |
| female sex (%) | 35 (42.7) | 13(37.1) | 22(62.9) | 0.38 |
| Weight(kg) | 4.9[3.4,12.8] | 4.4[3.3,37.9] | 4.9[3.4,11.3] | 0.91 |
| Weight for age z score | −1.2 ± 1.8 | −0.9 ± 1.7 | −1.4 ± 1.9 | 0.32 |
| Genetic syndrome (%) | 14 (17.1) | 7(50.0) | 7(50.0) | 0.54 |
| Single ventricle (%) | 37(45.1) | 15(40.5) | 22(59.5) | 0.72 |
| Single ventricle physiology (%) | 34(41.4) | 14(41.2) | 20(58.8) | 0.82 |
| Medical encounter (%) | 29(35.3) | 13(44.8) | 16(55.2) | 0.77 |
| Gestational age at birth, if age < 12 months at time of arrest (N = 50), weeks | 38.0[36.0,39.0] | 38.0[37.0,39.0] | 39.0[35.5,39.0] | 0.83 |
| Prior or Subsequent cardiac arrest during same admission (%) | 30(36.6) | 12(40.0) | 18(60.0) | 0.71 |
| Stat Category (N = 50) | ||||
| 1,2,or 3 (%) | 9 (18) | 4(44.4) | 5(55.6) | 0.93 |
| 4 (%) | 30 | 12(40.0) | 18(60.0) | |
| 5 (%) | 11 | 4(36.4) | 7(63.6) | |
| Cardiopulmonary bypass time (N = 44), minutes | 135.0[95.0,197.0] | 157.5[101.0, 182.0] | 116.0[82.0, 197.0] | 0.43 |
| Cross clamp time (N = 44), minutes | 68.0[38.0,122.0] | 110.0[49.0,130.0] | 53.5[35.0, 84.0] | 0.08 |
| Pre-arrest VIS 2 h | 3.2[0.0,8.0] | 4.8[1.0,7.0] | 2.7[0.0,8.7] | 0.52 |
| Intra-arrest | ||||
| CPR duration (min) | 37.2 ± 19.1 | 30.3 ± 15.1 | 42.3 ± 20.3 | 0.004 |
| Number of Epinephrine doses given | 7[5,11] | 6[3,8] | 8[6,13] | 0.003 |
| Epinephrine dosing interval | ||||
| < 5 min | 47(57.3) | 18(38.3) | 29(61.7) | 0.55 |
| 5–8 min | 17(20.7) | 8(47.1) | 9(52.9) | |
| More than 8 min | 15(18.3) | 8(53.3) | 7(46.7) | |
| Calcium given (%) | 65(79.3) | 25(38.5) | 40(61.5) | 0.13 |
| Number of Calcium doses given | 1[1,3] | 1[0,2] | 2[1,3] | 0.04 |
| Sodium bicarbonate given (%) | 64(78.0) | 28(43.8) | 36(56.3) | 0.71 |
| Number of sodium bicarbonate doses given | 1[1,3] | 1[1,2] | 1[1,3] | 0.53 |
| Shockable Rhythm (%) | 17(20.7) | 9(52.9) | 8(47.1) | 0.34 |
| Post arrest | ||||
| ECMO flow (ml/kg/min) mean over 6 h (N = 79) | 123 ± 47 | 122 ± 52 | 124 ± 44 | 0.82 |
| ECMO cannulation site | ||||
| Neck | 25 (30.4 %) | 8 (32 %) | 17(68 %) | 0.20 |
| Groin | 8 (9.8 %) | 4(50 %) | 4(50 %) | 0.66 |
| Chest | 49(68.1 %) | 23(46.9 %) | 26(53.1 %) | 0.34 |
| VIS mean 6 h | 3.4[1.0,6.4] | 3.9[0.6,6.7] | 2.8[1.0,6.1] | 0.66 |
| Vasodilator score mean over 6 h | 0[0,0] | 0[0,0] | 0[0,0] | 1.00 |
| Max Lactate | 14.0 ± 5.4 | 12.5 ± 4.4 | 15.1 ± 5.9 | 0.03 |
| Min lactate | 8.0 ± 5.2 | 7.3 ± 4.0 | 8.6 ± 5.9 | 0.24 |
All variables with normalized distribution expressed as mean ± STD. All variables with non-normalized distribution expressed as median [interquartile range].