Table 2.

Multivariable model on overall survival including allogeneic hematopoetic stem cell transformation as covariable.

Variable	adjusted HR	95% CI	p. value
Treated with mogamulizumab	0.34	0.15; 0.80	0.013
Diagnosis age (years): 50–59	0.86	0.34; 2.16	0.74
Diagnosis age (years): 60–69	1.39	0.59; 3.31	0.45
Diagnosis age (years): 70–79	2.49	1.07; 5.76	0.03
Diagnosis age (years):≥80	4.91	2.10; 11.46	<0.001
Cytologic transformation (diagnosis or follow-up)	2.82	1.57; 5.07	<0.001
LDH increase	1.07	0.65; 1.76	0.80
Eosinophilia	1.59	0.96; 2.64	0.07
Allogeneic hematopoietic stem cell transplantation	1.04	0.34; 3.19	0.94

Abbreviations: LDH, serum levels of lactate dehydrogenases; HR, hazard ratio; CI, confidence interval.

Hazard ratios (HRs) are estimated using Cox proportional hazard regressions. Multivariable HRs are obtained using models stratified on the number of received lines and that include age, disease stage, plasma lactate dehydrogenase (LDH) levels, large-cell transformation (time-dependent covariable), allogeneic stem cell transformation and eosinophilia as covariables.