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. 2024 Oct 24;12:1464773. doi: 10.3389/fcell.2024.1464773

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Copyright © 2024 Senese, Petito, Silvestri, Ventriglia, Mosca, Potenza, Russo, Falvo, Manfrevola, Cobellis, Chioccarelli, Porreca, Mele, Chianese, de Lange, Ricci, Cioffi and Lanni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CB1 deletion affects autophagy/mitophagy processes. (A), (B) and (C) Representative immunoblots of LC3B, p62, PARKIN, PINK1, AMBRA1, P-ULK (Ser555), FUNDC1 in the liver of CB1^+/+ and CB1^−/− mice. Histograms show the results of densiometric analysis of immunoblots. The protein level was normalized to that of B-ACTIN and/or to the total forms for phosphorylated proteins. (D) Representative images of liver ultrastructure under TEM in CB1^+/+ and CB1^−/− mice. Scale bars: 2 μm. Red arrows pointed towards autophagosomes. All values are represented as mean ± SEM; (n = 5/group). Student’s t-test was used for statistical analysis. p < 0.05 was considered significant. *p < 0.05 vs. CB1^+/+. Abbreviations: LC3B, Microtubule-Associated Protein 1 Light Chain 3 Isoform B; SQSTM1/p62, Sequestosome 1; PARKIN, Parkin; PINK1, PTEN-Induced Kinase 1; AMBRA1, Activating Molecule in Beclin1-Regulated Autophagy; ULK, Unc-51 Like Autophagy Activating Kinase 1; FUNDC1, FUN14 Domain Containing 1.