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. 2024 Nov 6;14:26994. doi: 10.1038/s41598-024-78467-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 9 — Upregulated SEMA3C in HCC tissues correlates with patient prognosis. (A) The mRNA levels of SEMA3C in 26 cases of HCC and their paired paracancerous tissues. (B) IHC scores of HCC and paired paracancerous tissues. (C) Scatterplot analysis of immunological scores in HCC and paired paracancerous tissues. (D,E) Representative immunohistochemical staining images of SEMA3C in nontumor, tumor, MVI (-) and MVI (+) tumor tissues. Original magnification, 200×, 400×. (F) IHC scores in MVI (-) tumor and MVI (+) tumor tissues. (G) KM curves show SEMA3C expression was correlated with OS. (H,I) SEMA3C mRNA and protein levels in human HCC cell lines (Huh7, Hep3B, HepG2, LM3, and MHCC97H). (J) Protein levels of SEMA3C in the NC group, sh-SEMA3C-1 group, sh-SEMA3C-2 group, and sh-SEMA3C-3 group in the MHCC97H cell line, as well as the protein levels of SEMA3C in the Vector group and SEMA3C group in the Huh7 cell line. ***P < 0.001.