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. 2024 Nov 6;15:9605. doi: 10.1038/s41467-024-53757-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a 3.4 Å global resolution cryo-EM map of the E1 structure, colored as in Fig. 1b. b Cartoon representation of the E1 state. c The Plug-domain (green) dips into and blocks the cytosol-facing cavity, inserted in between M2 and M4. Non-sharpened, Cryo-EM map (gray, transparent) at contour level 0.13, and non-sharpened density for the Plug-domain (green) at contour level 0.16. d Structural comparison of the apo E1 (gray) and E1-ATP states (colored domains) highlighting the movement of the SGE dephosphorylation loop. e Surface electrostatics of the E1-ATP state, with a deep cavity in the M-domain that is exposed to cytosol, unless blocked by the Plug-domain, which is not modeled. The close view is from the cytosol, showing that the cavity is lined by M2, M4, M5, and M6.