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. 2024 Oct 25;29(1):30. doi: 10.3892/ol.2024.14776

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Copyright: © 2024 Hsu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Nrf2 is differentially distributed in different cancer stages and subtypes of DLBCL. (A) Elevated NFE2L2 (Nrf2) mRNA levels in DLBCL tissues compared with in normal tissues. (B) Increased % Nrf2-positive cancer cells in advanced stages of DLBCL. (C) Higher frequency of Nrf2-positive cancer cells in the GCB subtype of DLBCL compared with that in the ABC subtype. (D) Higher Nrf2-positive cancer cell numbers in the GCB subtype across all stages of DLBCL. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. All IHC sample images are ×20 magnification. ns, no significance; DLBCL, diffuse large B-cell lymphoma; Nrf2, nuclear factor erythroid 2-related factor 2; ABC, activated B-cell; GCB, germinal center B-cell; TPM, transcripts per million; IHC, immunohistochemistry.