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. 2024 Oct 25;29(1):30. doi: 10.3892/ol.2024.14776

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Copyright: © 2024 Hsu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Keap1 expression in DLBCL, especially in the advanced staged and ABC subtype. (A) KEAP1 mRNA is significantly upregulated in DLBCL compared with that in the controls in The Cancer Genome Atlas and Genotype-Tissue Expression databases. (B) Significantly higher Keap1 expression in the advanced stages of DLBCL than in the early stages. (C) Significantly higher Keap1 expression in patients with DLBCL of the ABC subtype than the GCB subtype. (D) KEAP1 mRNA expression in DLBCL cell lines (HT and U2932). *P<0.05; **P<0.01. All IHC sample images are ×20 magnification. DLBCL, diffuse large B-cell lymphoma; Keap1, kelch-like ECH-associated protein 1; ABC, activated B-cell; GCB, germinal center B-cell; TPM, transcripts per million; IHC, immunohistochemistry.