Table I.
Basic clinical characteristics of the diffuse large B-cell lymphoma activated B-cell and germinal center B-cell subtypes.
| Clinical characteristic | ABC (n=30) | GCB (n=13) | P-value |
|---|---|---|---|
| Sex | 0.1854 | ||
| Male | 13 | 9 | |
| Female | 17 | 4 | |
| Age, years | 58.5 | 62.5 | 0.4313 |
| Ann Arbor stage | 0.4970 | ||
| 1-2 | 10 | 4 | |
| 3-4 | 20 | 9 | |
| ECOG performance status | 0.3607 | ||
| <2 | 25 | 10 | |
| ≥2 | 3 | 3 | |
| N.D. | 2 | 0 | |
| OS, months | 33.0±30.8 | 34.1±43.0 | 0.9240 |
| PFS, months | 28.2±32.0 | 34.1±43.0 | 0.6215 |
| HBsAg | 0.6972 | ||
| Positive | 6 | 2 | |
| Negative | 19 | 10 | |
| N.D. | 5 | 1 | |
| HBcAb | 0.4340 | ||
| Positive | 15 | 8 | |
| Negative | 10 | 2 | |
| N.D. | 5 | 3 | |
| HCV | 0.6594 | ||
| Positive | 4 | 3 | |
| Negative | 21 | 9 | |
| N.D. | 5 | 1 | |
| B symptomsb | 0.2953 | ||
| Positive | 14 | 4 | |
| Negative | 11 | 8 | |
| N.D. | 5 | 1 | |
| WBC, µl | 6,189.6±1,912.2 | 9,545.0±5,543.8 | 0.0096a |
| Platelet, ×103/µl | 230.5±118.9 | 257.7±129.1 | 0.5311 |
| LDH, U/l | 378.6±437.6 | 673.5±1091.9 | 0.2459 |
| β-2 microglobulin, µg/l | 435.9±483.1 | 306.9±215.9 | 0.4055 |
| Albumin, g/dl | 3.9±0.6 | 3.9±0.4 | 0.8598 |
| GOT, U/l | 31.6±18.9 | 45.9±46.2 | 0.1860 |
| GPT, U/l | 26.9±24.7 | 30.1±19.4 | 0.6960 |
| Blood urea nitrogen, mg/dl | 16.7±9.6 | 19.4±14.4 | 0.4981 |
| Creatinine, mg/dl | 1.38±2.1 | 1.52±2.2 | 0.8558 |
| Ionized calcium, mg/dl | 4.68±0.4 | 4.94±0.4 | 0.0945 |
| Chemotherapy courses | 5.93±2.25 | 3.75±3.05 | 0.0173a |
Data are presented as n or mean ± standard deviation.
a
P<0.05.
b
B symptoms: Fevers >38°C for at least 3 consecutive days, night sweats and body weight loss >10% during the 6 months prior to diagnosis. ABC, activated B-cell; GCB, germinal center B-cell; ECOG, Eastern Cooperative Oncology Group; OS, overall survival; PFS, progression-free survival; HBsAg, hepatitis B surface antigen; HBcAb, Hepatitis B core antibody; HCV, Hepatitis C virus; WBC, white blood cell; LDH, lactate dehydrogenase; GOT, glutamate oxaloacetate transaminase; GPT, glutamate pyruvate transaminase; N.D., not detected.