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. 2024 Oct 24;15:1473284. doi: 10.3389/fneur.2024.1473284

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Copyright © 2024 Alvarez, Steinman, Fox, Hartung, Qian, Wray, Robertson, Selmaj, Wynn, Mok, Xu, Bodhinathan, Miskin and Cree.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Components driving NEDA-3.^a *p < 0.0001. ^aParticipants may have > 1 component of evidence of disease activity. ^bIndependent Relapse Adjudication Committee confirmed. Pooled post hoc analysis. Modified intention-to-treat population. CDP, confirmed disease progression; Gd+, gadolinium-enhancing; NEDA-3, 3-parameter no evidence of disease activity. (A) Free of relapse. (B) Free of Gd+ T1 lesions. (C) Free of new/enlarging T2 lesions. (D) Free of 12-week CDP.