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Sample size calculations for a 12‐month randomized controlled trial of a disease modifying agent in an unstratified cohort versus a cohort with prognostic score >0.5
| Prognostic score | Baseline MDS‐UPDRS I + II; mean (SD) | MDS‐UPDRS I + II change/year | Power (%) | Significance | Sample size |
|---|---|---|---|---|---|
| All | 18.91 (9.36) | 3.05 | 80 | 0.05 | 296 |
| >0.5 | 21.62 (9.29) | 3.59 | 80 | 0.05 | 208 |
Abbreviations: MDS‐UPDRS, Movement Disorders Society—Unified Parkinson's Disease Score; SD, standard deviation.
