TABLE 3.
Association between specific motor scores and lateralized SBR
| Coefficient (SE), P‐value | ||||||
|---|---|---|---|---|---|---|
| Including most and least affected sides | Including least affected side only | |||||
| Combined trial cohorts | Disease duration ≤4 years | Disease duration >4 years | Combined trial cohorts | Disease duration ≤4 years | Disease duration >4 years | |
| Contralateral tremor | ||||||
| Whole striatum | −1.31 (0.47), 0.0055 | −1.67 (0.67), 0.0139 | −0.96 (0.77), 0.2168 | −0.33 (0.52), 0.5204 | −0.23 (0.71), 0.7474 | 0.01 (0.89), 0.9867 |
| Posterior putamen | −1.18 (0.73), 0.1043 | −1.55 (0.95), 0.1045 | −0.42 (1.25), 0.7367 | −0.32 (0.96), 0.7340 | 0.46 (1.17), 0.6983 | 0.34 (1.84), 0.8526 |
| Anterior putamen | −1.46 (0.48), 0.0027 | −1.84 (0.67), 0.0070 | −1.10 (0.80), 0.1724 | −0.54 (0.55), 0.3275 | −0.21 (0.74), 0.7777 | −0.36 (0.97), 0.7164 |
| Caudate | −0.83 (0.31), 0.0097 | −1.03 (0.47), 0.0283 | −0.60 (0.49), 0.2288 | −0.14 (0.32), 0.6705 | −0.11 (0.50), 0.8272 | 0.33 (0.48), 0.9442 |
| Contralateral bradykinesia | ||||||
| Whole striatum | −2.35 (0.57), <0.0001 | −1.37 (0.86), 0.1137 | −2.72 (0.88), 0.0023 | −1.39 (0.70), 0.0482 | −0.22 (1.04), 0.8325 | −1.66 (1.13), 0.1457 |
| Posterior putamen | −2.44 (0.89), 0.0064 | −1.77 (1.20), 0.1434 | −2.24 (1.45), 0.1232 | −2.14 (1.24), 0.0874 | 0.31 (1.54), 0.8409 | −1.43 (2.21), 0.5217 |
| Anterior putamen | −2.71 (0.58), <0.0001 | −1.71 (0.86), 0.0496 | −3.33 (0.90), 0.0003 | −1.65 (0.74), 0.0277 | −0.54 (1.10), 0.6245 | −2.02 (1.22), 0.1025 |
| Caudate | −1.36 (0.38), 0.0005 | −0.70 (0.60), 0.2475 | −1.40 (0.57), 0.0144 | −0.90 (0.48), 0.0641 | 0.24 (0.73), 0.7397 | −1.23 (0.72), 0.0919 |
| Contralateral rigidity | ||||||
| Whole striatum | −0.54 (0.29), 0.0642 | −0.71 (0.42), 0.0949 | −0.44 (0.48), 0.3637 | −0.08 (0.38), 0.8399 | −0.43 (0.59), 0.4721 | 0.21 (0.61), 0.7375 |
| Posterior putamen | −0.24 (0.45), 0.5912 | −0.38 (0.59), 0.5231 | 0.13 (0.77), 0.8624 | 0.08 (0.63), 0.9056 | 0.28 (0.80), 0.7242 | 0.90 (1.19), 0.4542 |
| Anterior putamen | −0.69 (0.30), 0.0214 | −0.73 (0.42), 0.0870 | −0.75 (0.49), 0.1290 | 0.02 (0.39), 0.9662 | −0.34 (0.58), 0.5611 | 0.37 (0.65), 0.5723 |
| Caudate | −0.32 (0.20), 0.1016 | −0.53 (0.29), 0.0730 | −0.17 (0.31), 0.5748 | 0.15 (0.25), 0.5517 | −0.19 (0.39), 0.6264 | 0.41 (0.37), 0.2809 |
Note: Bold indicates significant values.
Abbreviations: SBR, striatal binding ratio; SE, standard error.