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. 2024 Aug 7;11(11):1355–1364. doi: 10.1002/mdc3.14182

Video 1.

Typical progressive supranuclear palsy (PSP). Segment 1 shows a 61‐year‐old male of Indian (Gujarati) descent with classic PSP‐RS, who presented with gait imbalance and recurrent falls. The video taken 4 years after onset shows the typical features of hypomimia with a staring expression and frontalis overactivity. He exhibited blepharospasm when initiating eye movements. He had square‐wave jerks, vertical>horizontal supranuclear gaze palsy, dysarthria and severely impaired postural reflexes, requiring two person‐assistance to ambulate. He turned enbloc and had dystonic posturing in his right foot with a striatal toe. Segment 2 shows a 55‐year‐old Pakistani female with PSP‐P with corticobasal syndrome (CBS) overlap. This left‐handed woman presented with difficulty in writing and slowing of her gait. The video taken 3 years after onset shows hypomimia with frontalis overactivity, asymmetric (left > right) bradykinesia with corticobasal features of limb dystonia and apraxia on copying gestures in the left hand. Vertical saccadic slowing was better appreciated in a second video taken 2 years later. Her disease course was slightly atypical in its early age of onset and protracted duration of 14 years.