Inhibitory effect of compounds 13c, 7c & 11e against EGFR, TOP-II, HER-2 and aromatase enzymes.
| Comp. | IC50 (μM) | |||
|---|---|---|---|---|
| EGFR | TOP-II | HER-2 | ARO | |
| 13c | 0.087 | 31.56 | 0.078 | 0.156 |
| 7c | 0.169 | 48.48 | 0.21 | 0.567 |
| 11e | 0.246 | 36.72 | 0.116 | 0.38 |
| Lapatinib | 0.092 | |||
| Erlotenib | 0.032 | |||
| Doxorubicin | 33.97 | |||
| Ketoconazole | 0.092 | |||