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. 2024 Nov 7;14(48):35239–35254. doi: 10.1039/d4ra06704e

Inhibitory effect of compounds 13c, 7c & 11e against EGFR, TOP-II, HER-2 and aromatase enzymes.

Comp. IC50 (μM)
EGFR TOP-II HER-2 ARO
13c 0.087 31.56 0.078 0.156
7c 0.169 48.48 0.21 0.567
11e 0.246 36.72 0.116 0.38
Lapatinib 0.092
Erlotenib 0.032
Doxorubicin 33.97
Ketoconazole 0.092