Fig 4. Pharmakokinetics and tissue distribution of 4AZA2891.

(A) Sprague-Dawley rats (n = 3) were injected IV with 4AZA2891 at 2 mg/kg and blood was collected at the indicated time points. Plasma concentrations were measured using LC/MS/MS (lower limit of quantification of the bioanalysis: 10 ng/ml). (B, C) CD1 mice were injected IV with 4AZA2891 at 20 mg/kg and sacrificed at different time point post injection (3 mice per time point). (B) Concentration versus time curves of 4AZA2891 in plasma and brain. (C) Ratios of respective AUCs of organs over plasma.