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. 1983 Mar 15;210(3):783–787. doi: 10.1042/bj2100783

Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats.

M Bollen, L Hue, W Stalmans
PMCID: PMC1154290  PMID: 6409078

Abstract

The effects of glucose on phosphorylase and glycogen synthase were investigated in hepatocytes isolated from acutely (40 h) and chronically (90 h) alloxan-diabetic rats. The glucose-induced inactivation of phosphorylase proceeded normally in all conditions. The ensuing activation of glycogen synthase was slightly blunted in acute diabetes, but became virtually absent in 72 h diabetes of similar severity. In hepatocytes from rats with various degrees of chronic diabetes, the maximal activation of glycogen synthase (at 60 mM-glucose) was inversely correlated with the plasma glucose concentration.

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Selected References

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