Figure 4. AMPA receptor-mediated synaptic transmission requires wildtype dissociable PKA.

(A–C) Representative traces (red) normalized to the paired control (blue) (insets) and scatter plots of paired AMPA (A) and NMDA (B) receptor currents and AMPA/NMDA receptor current ratios (C) from neighboring untransfected CA1 neurons and those transfected with shRNA against PKA-C and the indicated shRNA-resistant rescue constructs. Statistical p values were obtained using a sign test (MATLAB). From left to right, n (neuron pairs)=13, 11, 11, and 15. Error bars represent s.e.m.