Comparison 1. Overall survival.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Stage of disease	4		Hazard Ratio (Random, 95% CI)	Subtotals only
1.1 Untreated patients	3	701	Hazard Ratio (Random, 95% CI)	0.97 [0.76, 1.24]
1.2 Relapsed patients	1	70	Hazard Ratio (Random, 95% CI)	0.40 [0.18, 0.89]
2 Rituximab‐containing regimen (previously untreated patients)	3	701	Hazard Ratio (Random, 95% CI)	0.97 [0.76, 1.24]
2.1 Rituximab in both arms	1	134	Hazard Ratio (Random, 95% CI)	0.88 [0.40, 1.92]
2.2 No rituximab in both arms	2	567	Hazard Ratio (Random, 95% CI)	0.98 [0.75, 1.28]