Comparison 3. Overall response rate.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All trials (previously untreated patients)	3	701	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.96, 1.34]
2 Rituximab‐containing regimen (previously untreated patients)	3	701	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.96, 1.34]
2.1 Rituximab in both arms	1	134	Risk Ratio (M‐H, Random, 95% CI)	1.29 [1.08, 1.54]
2.2 No rituximab in both arms	2	567	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.90, 1.27]