Comparison 4. Complete response rate.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All trials (previously untreated patients)	2	535	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.64, 1.92]
2 Rituximab‐containing regimen (previously untreated patients)	2	535	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.64, 1.92]
2.1 Rituximab in both arms	1	134	Risk Ratio (M‐H, Random, 95% CI)	1.37 [1.11, 1.70]
2.2 No rituximab in both arms	1	401	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.53, 1.33]