Table 2.
Neurological assessments of study participants undergoing skin biopsy.
| HV (n = 13) | No DPN (n = 7) | Painless DPN (n = 6) | Painful DPN (n = 15) | p-value | |
|---|---|---|---|---|---|
| NPSI (total score) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 20.8 (18.6) | <0.001 KW |
| DN4 | 0.0 (0.0) | 0.0 (0.0) | 2.0 (1.5) | 6.0 (3.5) | <0.001 KW |
| TCNS | 0.0 (0.0) | 2.0 (1.0) | 8.0 (10.0) | 15.0 (4.0) | <0.001 KW |
| NIS-LL | 0.0 (0.0) | 0.0 (3.0) | 9.0 (19.3) | 16.5 (10.0) | <0.001 KW |
| NIS-LL + 7 | 0.0 (1.0) | 0.0 (1.5) | 17.0 (23.7) | 25.2 (13.0) | <0.001 KW |
| Peroneal CMAP (mV) | 5.1 ± 1.7 | 5.4 ± 2.7 | 2.8 ± 3.2 | 2.1 ± 1.7 | 0.002 A |
| Peroneal MNCV (m/s) | 47.3 ± 3.3 | 46.7 ± 2.9 | 37.4 ± 9.7 | 38.9 ± 6.7 | <0.001 A |
| Peroneal MNDL (msec) | 4.9 (0.8) | 4.5 (0.9) | 6.6 (2.6) | 6.1 (4.7) | 0.005 KW |
| Tibial MNDL (msec) | 4.4 (1.2) | 4.7 (0.5) | 7.4 (2.9) | 6.8 (2.6) | <0.001 KW |
| Sural SNAP (mV) | 16.0 ± 6.4 | 11.1 ± 3.9 | 5.6 ± 4.9 | 2.9 ± 5.7 | <0.001 A |
| Foot ESC (μS) | 75.1 ± 10.9 | 74.2 ± 13.5 | 54.1 ± 19.8 | 43.4 ± 18.9 | <0.001 A |
| PGP 9.5 IENF fibres/mm | 17.4 ± 3.2 | 17.7 ± 3.6 | 7.9 ± 4.2 | 5.4 ± 5.2 | <0.001 A |
Boldface denotes p < 0.05.