| Taxanes (docetaxel, paclitaxel) |
Microtubule injury, mitochondrial damage, inflammatory cytokines, oxidative stress, direct axonal damage, voltage-gated-ion-channel dysfunction |
| Vinca alkaloids (vinblastine, vincristine) |
Microtubule injury |
| Platinum-based agents (cisplatin, carboplatin, oxaliplatin) |
Mitochondrial damage, inflammatory cytokines, oxidative stress, voltage-gated-ion-channel dysfunction, parasympathetic dysfunction |
| Proteasome inhibitors (bortezomib) |
Sphingolipid dysregulation, neuroinflammatory signaling pathway activation, mitochondrial damage, inflammatory cytokines, oxidative stress |
| Immune checkpoint inhibitors (ipilimumab, nivolumab, pembrolizumab) |
Possible autoimmunity |
