Table 3. Antibodies and cancers associated with paraneoplastic autonomic Dysfunction.

Antibody		Clinical phenotype	Associated cancers
High-risk antibodies
	SOX-1	LEMS	SCLC, NSCLC
	CV2/CRMP5	Autonomic neuropathy	SCLC, thymoma, NSCLC
	Hu	Pandysautonomia	SCLC
Intermediate-risk antibodies
	P/Q-type VGCCs	LEMS	SCLC
	CASPR2	Morvan syndrome	Thymoma

CASPR2, contactin-associated protein-like 2; CRMP5, collapsing response-mediator protein 5; LEMS, Lambert-Eaton myasthenic syndrome; NSCLC, non-SCLC; SCLC, small-cell lung cancer; SOX-1, Sry-like high-mobility group box-1; VGCCs, voltage-gated calcium channels.