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. 2024 Oct 25;12:1447630. doi: 10.3389/fcell.2024.1447630

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Copyright © 2024 Sanovec, Frolikova, Kraus, Vondrakova, Qasemi, Spevakova, Simonik, Moritz, Caswell, Liska, Ded, Cerny, Avidor-Reiss, Hammoud, Schorle, Postlerova, Steger and Komrskova.

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Protamine 2 deletion resulted in aberrant Septin12 localization in epididymal sperm. (A) Left panel: A localization of Septin 12 in WT sperm connecting piece (white arrow), annulus (yellow arrow), and midpiece (the area between arrows). Right panel: A mislocalization of Septin 12 in the tail of four morphologically aberrant types of Prm2^−/− sperm. Septin 12 (green) and DAPI (Blue), scale bar = 5 µm. (B) Annulus (yellow arrows) detail visualized by cryoelectron microscopy. Scale bar = 500 nm. (C) Scatterplot visualizing statistical evaluation of mean annulus area and mean of annulus distance from centroid to centroid within one sperm. Mann-Whitney test, n = 13 (WT) and 11 (Prm2^−/− ).