Table 1.
Demographic data of the cohort used for the investigation of co-morbid depression in Alzheimer's disease.
| AD without depression (AD only) n = 25 | AD with depression (AD + MDD) n = 23 | Statistical analysis (χ2 test, ANOVA or Mann Whitney U test) | |
|---|---|---|---|
| Sex: Male: Female | 10:15 | 13:10 | Χ2 = 1.310, p = 0.252 |
| Age at death (years), Mean ± SD | 82.8 (7.8) | 78.7 (9.9) | p = 0.116 |
| Duration of AD (years) | 7.3 (4.2) | 8.7 (3.3) | p = 0.285 |
| Mean ± SD | |||
| Last documented MMSE score | 14.8 (8.0) | 15.1 (6.8) | p = 0.939 |
| Mean ± SD | |||
| Braak stage | Χ2 = 2.140, p = 0.544 | ||
| III | 2 | 1 | |
| IV | 1 | 1 | |
| V | 8 | 12 | |
| VI | 14 | 9 | |
| APOE genotype | |||
| 2/3 | 2 | 0 | |
| 2/4 | 3 | 2 | |
| 3/3 | 7 | 5 | |
| 3/4 | 5 | 5 | |
| 4/4 | 0 | 4 | Χ2 = 6.510, p = 0.164 |
| Thal phase | |||
| Unknown | 1 | 0 | |
| 3 | 2 | 0 | |
| 4 | 15 | 18 | |
| 5 | 7 | 5 | Χ2 = 3.529, p = 0.317 |
| LATE stage | |||
| Unknown | 24 | 22 | |
| Negative | 1 | 0 | |
| 2 | 0 | 1 | Χ2 = 2.007, p = 0.367 |
| Braak lewy body stage | |||
| Unknown | 7 | 9 | |
| Unclassifiable | 1 | 0 | |
| 0 | 17 | 13 | |
| 2 | 0 | 1 | Χ2 = 2.705, p = 0.439 |
| CERAD | |||
| No plaques | 1 | 0 | |
| Sparse | 1 | 1 | |
| Moderate | 1 | 4 | |
| High | 22 | 18 | Χ2 = 3.122, p = 0.373 |
| Post-mortem delay (hours) | |||
| Mean ± SD | 30.2 (14.6) | 40.4 (20.0) | p = 0.0683 |
| Use of antidepressant medication in last 12 months | |||
| No | 20 | 6 | |
| Yes | 5 | 17 | Χ2 = 14.025, p < 0.001 |
| Use of antipsychotic medication in last 12 months | |||
| No | 20 | 16 | |
| Yes | 5 | 7 | Χ2 = 0.696, p = 0.404 |
| Use of anti-inflammatory medication in last 12 m | |||
| No | 7 | 10 | |
| Yes | 16 | 13 | Χ2 = 0.840, p = 0.359 |
| Evidence of co-morbid inflammatory condition | |||
| No | 6 | 15 | |
| Yes | 19 | 8 | Χ2 = 8.270, p = 0.004 |