Ciprofol is a new type of non-barbiturate general intravenous anesthetic. Clinical trials have shown that ciprofol has the advantages of fast onset, fast recovery, and less injection pain. However, there are few studies comparing the hemodynamic stability, injection pain, and adverse reactions of ciprofol and propofol during painless colonoscopy.

In this study, we aimed to investigate that ciprofol is superior to propofol in terms of hemodynamic stability and injection pain in patients undergoing painless colonoscopy.

Ciprofol sedation was safe and effective for anesthesia induction during colonoscopy procedures, with a decrease in injection pain and a lower blood pressure reduction observed relative to propofol sedation.

Intravenous injection of ciprofol has a superior hemodynamic stability with lower incidence of injection pain and higher patient satisfaction compared with propofol for sedation during painless colonoscopy.