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. 2024 Nov 8;9:302. doi: 10.1038/s41392-024-02005-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Historical narrative of important milestones in NK cell research. Interrogation of the historical record of natural killer cell research from PubMed using the keywords “Natural Killer cells”, “Natural Killer cells and Immunotherapy”, “Natural Killer cells and CAR-NK”, and “Natural Killer cells and Covid”. We provide in the main text of the review a year-by-year narrative of the progress/discovery culminating in the offering of CAR-NK as an “experimental therapy” against cancer at MD Anderson cancer center. In 2021, the number of publications related to “NK cells” is 3.57-fold less than “T-Cells” and the research record of “CAR-NK” is even more minuscule. Both fields show a subsequent slump in research publications in the period 2020–2023 which may be due to the Covid-19 pandemic