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. 2024 Nov 8;9:302. doi: 10.1038/s41392-024-02005-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — SHP-1 content is modulated by licensing and determines the degree of activation. CD56^bright uneducated NK cells respond to inhibitory signals with strong production of phosphatase SHP-1, leading to their rapid inactivation, while educated, licensed CD56^dim NK cells have reduced SHP-1 production when responding to inhibitory ligands, allowing them to resist deactivation