Table 2.

List of human clonal NK cell lines

Cell line	Year established/published	Patient diagnosis	Age of donor	Sex	EBV status	Cytokine dependence	Clinical Trials
NK3.3	1982	Cloning of primary MLC-activated cells in a medium containing interleukin-2	N/A	N/A	EBV−	IL-2-dependent	NO
YT	1983	Acute lymphoblastic lymphoma (with thymoma)	15	Male	EBV+	IL-2-independent	NO
NK-92	1992/1994	LGL-NHL	50	Male	EBV−	IL-2-dependent	Yes (Table 1)
NKL	1996	NK-LGLL	63	Male	EBV−	IL-2-dependent	NO
NK-YS	1996	NK cell lymphoma, Nasal angiocentric, Leukemic state with systemic skin infiltration	19	Female	EBV+	IL-2-dependent	NO
KHYG-1	1997	Aggressive NK leukemia	45	Female	EBV−	IL-2-dependent	NO
HANK1	1998	Nasal-like NK/T-cell lymphoma	46	Female	EBV+	IL-2-dependent	NO
SNK-6	1998	Nasal NK/T-cell lymphoma	62	Male	EBV+	IL-2-dependent	NO
SNT-8	1998	Nasal NK/T-cell lymphoma	48	Female	EBV+	IL-2-dependent	NO
IMC-1	2004	Aggressive NK cell leukemia	42	Male	EBV−	IL-2-dependent	NO

LGL large granular lymphocyte, LGLL large granular lymphocyte leukemia, NHL non-Hodgkin’s lymphoma, EBV Epstein-Barr virus