Fig. 3.

Tumor response. a Waterfall plot of maximum percent change in tumor size from baseline in each patient as measured by Response Evaluation Criteria in Solid Tumors (version 1.1). ^* Patients whose PD status was documented due to the appearance of new lesions. b Swimmer-plot of time on treatment. c Longitudinal change in tumor size from baseline. ^# NE indicates patients with unevaluable post-baseline assessment or no post-baseline assessment available for tumor response. CR complete response, PR partial response, PD progressive disease, SD stable disease, NE not evaluable