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. 2024 Oct 25;15:1475179. doi: 10.3389/fimmu.2024.1475179

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Copyright © 2024 Yamada, Nagafuchi, Yamada, Suzuki, Natsumoto, Ota, Takazawa, Hatano, Kono, Harada, Shoda, Okamura, Kosaki and Fujio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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eQTL analysis of the SLE risk IKBKE variant. (A) The cis-eQTL effect beta by this allele. A positive beta corresponds to an increase in gene expression due to the risk allele. The error bars represent the 95% confidence interval. (B) cis-eQTL effects boxplots on the expression of IKBKE across cell subsets. G is a risk allele for systemic lupus erythematosus. The p-value represents the association of eQTL (linear regression) p-values. Below the boxplot are the sample sizes for each group. Naïve CD4, Naïve CD4 T cells; Mem CD4, Memory CD4 T cells; Th1, T helper 1 cells; Th2, T helper 2 cells; Th17, T helper 17 cells; Tfh, T follicular helper cells; Fr. I nTreg, Fraction I naïve regulatory T cells; Fr. II eTreg, Fraction II effector regulatory T cells; Fr. III T, Fraction III non-regulatory T cells; Naïve CD8, Naïve CD8 T cells; CM CD8, Central memory CD8 T cells; EM CD8, Effector memory CD8 T cells; TEMRA CD8, CD8+ T effector memory CD45RA+ cells; NK,Natural killer cells; Naïve B, Naïve B cells; USM B, Unswitched memory B cells; SM B, Switched memory B cells; DN B, Double negative B cells; Plasmablast, Plasmablasts; CL Mono, Classical monocytes; CD16p Mono, CD16 positive monocytes, Int Mono, Intermediate monocytes; NC Mono, Non-classical monocytes; mDC, Myeloid dendritic cells; pDC, Plasmacytoid dendritic cells.