Figure 2.

Structural types and characteristics of PROTAC linkers. (A) The frequency of occurrence of each type of linker in PROTACs encompasses the period from the initial report of PROTAC in 2001 up until the end of 2023. We have only counted the linker in the most effective PROTAC described in each publication. (B) A timeline has been created to indicate the initial appearance of each linker type in the scientific literature. (C) The linker characteristics that impact the biodegradation efficiency of the PROTAC have been identified.