Table 3.
Total and Differential Cell Count of Sputum Samples from Patients with Severe Asthma in the Discovery Cohort
| Patients with Eosinophil-enriched Sputa* (n = 22) | Patients with Non–Eosinophil-enriched Sputa† (n = 14) | P Value | |
|---|---|---|---|
| Total cells, ×106/g | 3.02 (1.03–5.51) | 2.86 (1.46–3.84) | 0,88 |
| Eosinophils, % | 5.37 (3.00–8.75) | 0.37 (0.25–0.93) | <0.0001 |
| Eosinophils, ×106/g | 0.09 (0.08–0.20) | 0.012 (0.007–0.03) | <0.0001 |
| Neutrophils, % | 74.62 (65.01–83.37) | 77.52 (64.43–91.95) | 0.39 |
| Neutrophils, ×106/g | 1.82 (0.63–3.72) | 1.84 (0.97–2.85) | 0.88 |
| Macrophages, % | 14.33 (6.87–23.12) | 11.37 (5.5–30.25) | 0.73 |
| Macrophages, ×106/g | 0.40 (0.13–1.10) | 0.27 (0.14–0.82) | 0.66 |
| Lymphocytes, % | 0.39 (0.00–0.75) | 0.87 (0.31–1.75) | 0.14 |
| Columnar epithelial cells, % | 3.75 (0.76–5.50) | 3.25 (1.31–6.68) | 0.57 |
| Squamous cells, % | 1.91 (0.03–5.35) | 5.35 (2.43–8.51) | 0.08 |
| Viability, % | 69.86 (61.45–83.50) | 68.55 (55.28–74.85) | 0.76 |
| Plug weight, mg | 189.5 (106.5–264.25) | 141.5 (57.75–213.75) | 0.51 |
Data are summarized as median (Q1–Q3). A nonparametric test (Mann-Whitney) was performed for continuous variables.
*
Sputum eosinophils ⩾ 3%.
†
Sputum eosinophils < 3%.