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Human iPS–derived cardiomyocyte (iCM) mitosis and cytokinesis visualized using time-lapse live cell confocal imaging (micrographs at ~15-min intervals). Sarcomere Z-disk structures as demonstrated by alpha actinin 2-GFP signal disassemble during early stages of mitosis and reassemble after mitosis. White arrow denotes multinuclear iCM, while red arrow denotes a mononuclear iCM (top left image) that successfully completes cytokinesis (bottom right image). Scale bar = 10 μ
