FIGURE 3.

Depression and anxiety level of mice. The forced swim test was used to evaluate the level of depression. In both genders, the duration of immobility was comparable among genotypes (A). The anxiety level of mice was assessed using an elevated plus maze. The time spent in open arms, closed arms, and the central region was measured (B). Male FbCcn2 ^−/− mice spent more time in closed arms than male FbCcn2 ^+/+ mice, indicating a high anxiety level. In female mice, the time spent in all regions was comparable among genotypes. N = 5 mice in each condition. Results are mean ± SEM. *p < 0.05.