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. 2024 Oct 23;18(44):30211–30223. doi: 10.1021/acsnano.4c09830

Figure 8.

Figure 8

Dual-modal CNPs for continuous neurotoxin detoxification. (A) Schematic representation of neuronal membrane-coated ZIF-8 core encapsulating N-sulfotransferase (denoted “Neuron-MOF/SxtN-NPs” in the original study, ref (44)) illustrating dual-modal STX detoxification: STX binding by neuronal membrane receptors and STX degradation by encapsulated SxtN enzyme. (B) A representative TEM image of Neuron-MOF/SxtN-NPs (scale bar = 1 μm). Inset: a zoomed-in image of the nanoparticles showing a visible membrane shell enveloping a core (scale bar = 100 nm). (C) In a treatment regimen, survival rates of mice subcutaneously injected with 4.75 μg kg–1 STX, followed by intravenous administration of either Neuron-MOF/SxtN-NPs or Neuron-MOF-NPs in 5 min. (D) In a prevention regimen, survival rates of mice intravenously administered with either Neuron-MOF/SxtN-NPs or Neuron-MOF-NPs, followed by subcutaneous injection of 4.75 μg kg–1 STX after 5 min. Adapted with permission from ref (45). Copyright 2024 American Chemical Society.