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. 2024 Oct 23;18(44):30211–30223. doi: 10.1021/acsnano.4c09830

Table 5. Summary of Synthesis Principles of Major CNPs Reviewed in This Article.

Construct feature Synthesis principle Reference
CNPs with cell membrane and solid core (without payload) Purified cell membrane is coated onto nanoparticle core via sonication or extrusion (5), (29)
CNPs with cell membrane and oil core Oil droplets are added to membrane suspension, followed by sonication (40)
CNPs with cell membrane and MOF core (with enzyme payload) MOF building blocks and enzyme payload are mixed with membrane vesicles, followed by extrusion (43), (51)
CNPs coated with a hybrid membrane Different cell membranes are combined and sonicated for hybridization, and the resulting hybrid membrane is then used to formulate CNPs (54)
Lure-and-kill CNPs Lipid-like PLA2 inhibitors are mixed with cell membrane and sonicated, and the resulting membrane is then used for coating, followed by doping with melittin (37)