Figure 4.

Development of a drug-like ligand to target three cyclins simultaneously. (A) Cyclins A1, D2, and E1 are key hubs of the AML network. Complexes of these cyclins with their CDK partners regulate key processes during the cell cycle. CDK4/6/cyclin D complexes act in phase G1, and CDK2/cyclin E complexes act when G1/S transition takes place. The CDK2/cyclin A complex regulates progression through the S phase and the CDK1/cyclin A complex through the G2 phase in preparation for mitosis (M). (B) Chemical structure of the triple-targeting cyclin protein ligand that was generated by LigBuilder V3.