Table 2.
Baseline characteristics of the included studies.
| Study ID | Location of Study | Study Design | Sample Size | Sex, Male n (%) |
Age, Years Mean (SD) |
Total Radiation Dose, GyRBE Median (IQR) |
Gross Total (GTR) or Near Total (NTR) at Time of Radiation n (%) |
|---|---|---|---|---|---|---|---|
| Gentile 2017 [6] | USA | Cohort | 216 | 126 (58.3%) | 6.6 (3.77) | 54 (46.8–59.4) | 187 (86.6%) |
| Indelicato 2021 [24] | USA | Cohort | 29 | 20 (69%) | 14.8 (4.5) | NR | 17 (59%) |
| Indelicato 2014 [9] | USA | Cohort | 313 | 168 (53.7%) | 5.9 (2.9) | NR | 109 (34.8%) |
| Indelicato 2021 [25] | USA | Cohort | 386 | 216 (55.9%) | 3.8 (3.43) | 55.8 (50.4–59.4) | 328 (85%) |
| Upadhyay 2022 [26] | USA | Cohort | 468 | 263 (56.2%) | 6.25 (3.1) | 54 (39.6–59.4) | 288 (63.4%) |
| Orukari 2022 [27] | USA | Cohort | 58 | 38 (65.5%) | 10.3 (5.225) | 54 (50.4–60) | 52 (90%) |
| Gunther 2015 [13] | USA | Cohort | 37 | 22 (59%) | 3.01 (0.97) | 59.4 (53.0–59.4) | 37 (100%) |
| Vogel 2019 [16] | USA | Cohort | 166 | 107 (64%) | 10 (3.42) | 54.0 (30.0–63.0) | 100 (60%) |
| Patteson 2021 [28] | USA | Cohort | 150 | 81 (54.0%) | 3.6 (3.43) | 54 (50.4–59.4) | 121 (80.6%) |
| Tran 2020 [29] | Switzerland | Cohort | 221 | 129 (58.4%) | 4.1 (2.9) | 54 (18–64.8) | 79 (35.7%) |
| Indelicato 2017 [30] | UK | Cohort | 166 | 90 (54%) | NR | NR | NR |
SD: standard deviation, NR: not reported, IQR: interquartile range, RBE: relative biological effectiveness.