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Galactose reduces sensitivity to one-carbon metabolism inhibitors. (A) IC50 curves of Molm13 and THP1 cells treated with SHIN1 and 5-FU. Cells were previously adapted for 6 days’ growth in media containing either glucose, fructose or galactose. Relative survival of Molm13 and THP1 treated with 5-FU or SHIN1 at approximately IC50 concentrations. (B) Schematic displaying the one-carbon metabolism inhibitors [19,20].
