Table 2.

Univariable and multivariable Cox regression models addressing rates of biochemical recurrence (BCR) after radical prostatectomy (RP), according to presence vs. absence of lymphovascular invasion or perineural invasion in RP specimens.

	Univariable			Multivariable *
	HR	95% CI	p-Value	HR	95% CI	p-Value
Lymphovascular invasion (Ref. no)	1.58	1.01, 2.47	0.045	0.91	0.50, 1.63	0.740
Perineural invasion (Ref. no)	1.77	1.13, 2.77	0.013	1.26	0.78, 2.04	0.341

* adjusted for age at surgery, PSA value, pTstage, Gleason Grade Group, pNstage, positive surgical margin, surgical approach, and adjuvant radiation therapy. Abbreviations: CI = confidence interval; HR = hazard ratio; pN = pathologic lymph node stage; PSA = prostate-specific antigen; pT = pathologic tumor stage. Bold highlights statistically significant hazard ratio and corresponding p-value.