Table 2.

Risk of bias for in vivo studies (SYRCLE’s RoB tool).

Study	Item 1	Item 2	Item 3	Item 4	Item 5	Item 6	Item 7	Item 8	Item 9	Item 10
Takamura et al., 2011 [11]	No	No	No	No	No	No	No	Unclear	No	Unclear
Liu et al., 2019 [13]	No	Yes	Yes	Yes	Yes	Yes	No	Unclear	Yes	Yes
Xie Z et al., 2022 [15]	No	Yes	Yes	Yes	Yes	Yes	No	No	Unclear	Yes
Zelante et al., 2013 [16]	No	Yes	Yes	Yes	Yes	No	No	No	Yes	Yes
Fukumoto et al., 2014 [17]	No	Unclear	Unclear	Unclear	Yes	Unclear	No	No	Yes	No
Lamas et al., 2016 [18]	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Hou et al., 2018 [19]	No	Yes	Yes	Yes	Yes	Unclear	No	Yes	Yes	Yes
Lamas et al., 2020 [26]	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No
Gu et al., 2021 [20]	No	Yes	Yes	Yes	Yes	Unclear	No	Unclear	Yes	Yes
Li et al., 2021 [21]	No	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes
Cui et al., 2022 [22]	No	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes
Cui et al., 2023 [23]	No	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes
Park et al., 2023 [24]	No	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes
Xia et al., 2023 [25]	No	Yes	Yes	Yes	Yes	Yes	No	No	Yes	Yes