Table 2.
The association of HAO1 gene copy number with clinicopathological and biological markers in invasive breast cancer (METABRIC). Statistically significant p-values shown in bold.
| HAO1 Copy Number | ||||||
|---|---|---|---|---|---|---|
| Loss n (%) | Neutral n (%) | Gain n (%) | χ2 (p-Value) | Total n | ||
| Histological Type | ||||||
| Ductal carcinoma, No Special Type | 24 (2) | 1378 (89) | 142 (9) | 24.4 (0.007) |
1544 | |
| Lobular mixed | 0 (0) | 81 (90) | 9 (10) | 90 | ||
| Tubular | 0 (0) | 67 (100) | 0 (0) | 67 | ||
| Mucinous | 2 (4) | 44 (96) | 0 (0) | 46 | ||
| Medullary | 0 (0) | 32 (100) | 0 (0) | 32 | ||
| Lobular | 2 (1) | 139 (95) | 6 (4) | 147 | ||
| Tumour Size | ||||||
| <2.0 cm | 0 (0) | 12 (80) | 3 (20) | 2.8 (0.250) |
15 | |
| ≥2.0 cm | 27 (2) | 1756 (90) | 162 (8) | 1960 | ||
| Grade | ||||||
| 1 | 3 (2) | 159 (93) | 8 (5) | 6.2 (0.188) |
170 | |
| 2 | 8 (1) | 703 (91) | 59 (8) | 770 | ||
| 3 | 16 (2) | 847 (89) | 89 (9) | 952 | ||
| Lymph Node Stage | ||||||
| 1 | 14 (1) | 943 (91) | 78 (8) | 1.8 (0.773) |
1035 | |
| 2 | 9 (1) | 555 (89) | 58 (10) | 622 | ||
| 3 | 5 (1) | 284 (90) | 27 (9) | 316 | ||
| Receptor Status | ||||||
| ER | + | 23 (1) | 1355 (90) | 128 (9) | 0.8 (0.660) |
1506 |
| − | 5 (1) | 432 (91) | 37 (8) | 474 | ||
| PR | + | 13 (1) | 941 (91) | 86 (8) | 0.4 (0.802) |
1040 |
| − | 15 (2) | 846 (90) | 79 (8) | 940 | ||
| HER2 | + | 4 (1) | 229 (93) | 14 (6) | 2.7 (0.262) |
247 |
| − | 24 (1) | 1558 (90) | 151 (9) | 1733 | ||
| PAM50 Subtypes | ||||||
| Luminal A | 6 (1) | 665 (93) | 47 (6) | 25.6 (0.001) |
718 | |
| Luminal B | 14 (3) | 417 (85) | 57 (12) | 488 | ||
| HER2-E | 3 (1) | 216 (90) | 21 (9) | 240 | ||
| Basal-like | 4 (1) | 295 (90) | 30 (9) | 329 | ||
| Normal-like | 1 (1) | 189 (95) | 9 (5) | 199 | ||