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. 2024 Oct 29;25(21):11629. doi: 10.3390/ijms252111629

Table 1.

Dietary intervention studies. BCAA: Branched-chain Amino Acids. DA: dopamine. FMD: Fasting-mimicking Diet. MPTP: 1-Methyl-4-phenil-1,2,3,6-tetrahydropyridine.

PD Model Intervention
Author Model Toxic Dose Duration Administration Diet Duration Administration Results
[19] C57BL6 mice MPTP 25 mg/kg 35 days Intraperitoneal Ketone diet (MCT-KD) 42 days Oral Protection against the loss of DA neurons and alterations in the gut microbiota and its metabolites.
[20] 7 days High-BCAAs (H-BCAA) 56 days Relief of both motor and non-motor symptoms, promoting SCFAs.
[21] Rotenone 30 mg/kg 21 days/28 days Gavage 360 days Anti-inflammatory effect in the gut and brain
[22] MPTP 20 mg/kg Intraperitoneal Fasting-mimicking diet (FMD) Three 7-day cycles (FMD for 3 consecutive days in each cycle) Recovery of motor function, mitigation of loss of dopaminergic neurons, and increase in DA and 5-HT levels.