Table 1.
PD Model | Intervention | ||||||||
---|---|---|---|---|---|---|---|---|---|
Author | Model | Toxic | Dose | Duration | Administration | Diet | Duration | Administration | Results |
[19] | C57BL6 mice | MPTP | 25 mg/kg | 35 days | Intraperitoneal | Ketone diet (MCT-KD) | 42 days | Oral | Protection against the loss of DA neurons and alterations in the gut microbiota and its metabolites. |
[20] | 7 days | High-BCAAs (H-BCAA) | 56 days | Relief of both motor and non-motor symptoms, promoting SCFAs. | |||||
[21] | Rotenone | 30 mg/kg | 21 days/28 days | Gavage | 360 days | Anti-inflammatory effect in the gut and brain | |||
[22] | MPTP | 20 mg/kg | Intraperitoneal | Fasting-mimicking diet (FMD) | Three 7-day cycles (FMD for 3 consecutive days in each cycle) | Recovery of motor function, mitigation of loss of dopaminergic neurons, and increase in DA and 5-HT levels. |