Table 1.
Radiological, clinical and functional features of patients enrolled in the study.
| Overall Population | Rheumatoid Arthritis | Primary Sjogren’s Syndrome | p | |
|---|---|---|---|---|
| Number | 232 | 156 | 76 | |
| Males, n (%) | 78 (33.6) | 63 (40.4) | 15 (19.7) | 0.002 |
| Smoking habit, n (%) | 99 (42.7) | 74 (47.4) | 25 (32.9) | 0.037 |
| Cough at baseline, n (%) | 159 (68.5) | 104 (66.7) | 55 (72.5) | 0.072 |
| Dyspnea at baseline, n (%) | 163 (70.2) | 108 (69.2) | 55 (72.5) | 0.349 |
| ILD preceding RD, n (%) | 81 (34.9) | 47 (30.1) | 34 (44.7) | <0.001 |
| UIP pattern, n (%) | 104 (44.8) | 79 (50.6) | 25 (32.9) | 0.012 |
| Fibrosing, n (%) | 169 (72.8) | 121 (77.6) | 48 (63.2) | 0.027 |
| Fibrosing Progressive, n (%) | 90 (38.8) | 63 (40.4) | 27 (35.5) | 0.566 |
| FVC% at baseline | 91 (77, 105) | 91 (78, 102) | 91.5 (76, 106.75) | 0.881 |
| DLCO% at baseline | 58 (44, 73) | 59 (47, 72) | 58 (42, 75) | 0.551 |
| 24 month-FVC% decline | 3 (−3, 11) | 3 (0, 12) | 2 (−6, 10) | 0.042 |
| 24 month-DLCO% decline | 1 (−6, 10) | 4 (−2, 13) | −1 (−14, 8) | 0.003 |
| Median age at RD diagnosis (years, IQR) | 63 (53, 71) | 59 (52, 67) | 68.5 (59.5, 75) | <0.001 |
| Median age at ILD diagnosis (years, IQR) | 67.5 (60, 70) | 68 (59, 73) | 67 (62, 74.5) | 0.445 |
| Median age at enrolment (years, IQR) | 70 (62, 76) | 70 (62, 76) | 70.5 (63, 78) | 0.461 |
Results are reported as number (percentage) or as median (interquartile range); unless specified, data are referred to the enrolment. ILD: interstitial lung disease; UIP: usual interstitial pneumonia; RD: rheumatic disease; FVC: forced vital capacity % predicted; DLCO: diffusion lung of carbon monoxide % predicted.