Table 2.
Hepatic Bile Acid Composition
| nmol/g tissue | fl/fl |
iKO |
Fold change | P value | ||
|---|---|---|---|---|---|---|
| Average | SEM | Average | SEM | |||
| Total MCA | 339.3 | 42.88 | 512.14 | 54.95 | 1.5 | .021 |
| aMCA | 1.85 | 0.32 | 2.64 | 0.29 | 1.4 | .088 |
| bMCA | 22.83 | 3.21 | 27.03 | 2.75 | 1.2 | .346 |
| CA | 4.36 | 1.13 | 9.61 | 3.19 | 2.2 | .124 |
| TCA | 235.81 | 32.68 | 493.14 | 70.33 | 2.1 | .002 |
| GCA | 0.31 | 0.09 | NF | NF | ||
| CDCA | 0.52 | 0.06 | 0.83 | 0.15 | 1.6 | .049 |
| TCDCA | 12.98 | 1.6 | 21.75 | 2.04 | 1.7 | .003 |
| GCDCA | NF | NF | NF | NF | ||
| UDCA | NF | NF | NF | NF | ||
| TUDCA | 9.99 | 1.37 | 15.01 | 1.98 | 1.5 | .046 |
| GUDCA | NF | NF | NF | NF | ||
| wMCA | 13.75 | 2.21 | 11.52 | 1.74 | 0.8 | .453 |
| DCA | 0.58 | 0.09 | 0.77 | 0.19 | 1.3 | .365 |
| TDCA | 18.12 | 3.01 | 21.81 | 3.01 | 1.2 | .402 |
| GDCA | NF | NF | NF | NF | ||
| THDCA | 3.99 | 0.55 | 3.71 | 0.57 | 0.9 | .733 |
| HDCA | NF | NF | NF | NF | ||
| TLCA | 1.31 | 0.07 | 1.37 | 0.09 | 1.0 | .558 |
| GLCA | NF | NF | NF | NF | ||
iKO, Intestine-specific knockout; SEM, standard error of the mean. fl/fl n = 11, iKO n = 12
Boldfaced P values indicate statistical significance.