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. Author manuscript; available in PMC: 2025 Nov 1.
Published in final edited form as: J Pediatr Surg. 2024 Jul 18;59(11):161632. doi: 10.1016/j.jpedsurg.2024.07.017

Figure 3. Hematoxylin and eosin-stained photomicrographs of gonadal tissue demonstrating involvement by various malignant neoplasms.

Figure 3

Biopsy specimen from patient 1 contains malignant mixed germ cell tumor composed of immature teratoma with immature neuroepithelium (A, black arrow) and a closely associated yolk sac component (A, blue arrow) is shown within the ovarian tissue (A, inset) with adjacent viable follicles (A, inset, red arrows). The biopsy from patient 2 contains tongue-like projections of desmoplastic small round cell tumor (B, blue arrows) invading adjacent ovarian tissue (B, green star) contain viable follicles (B, inset, red arrows). Biopsy from patient 3 shows malignant small round blue cell tumor (C, blue star) invading into ovarian tissue (C, green star) that contains viable follicles (C, top inset, red arrow). The malignancy shows architecture resembling sac-like alveoli of the lung (C, bottom inset), consistent with alveolar rhabdomyosarcoma. Biopsy specimen from patient 4 contains ovarian tissue with viable follicles (D, red arrows) infiltrated by sheets of B-lymphoblasts, consistent with B-cell acute lymphoblastic leukemia/lymphoma (D, blue star). Scale bars in each frame are 50μm.