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. 2024 Nov 1;25(21):11764. doi: 10.3390/ijms252111764

Figure 5.

Figure 5

Inhaled CBD shifts immune profile in meninges of mice with AD towards the normal status. (a,b) Flow cytometry analysis showed depletion of meningeal ILC2s in 5xFAD mice with AD compared to the WT mice. Inhaled CBD reversed such alteration towards the normal status. (c) Quantification of meningeal ILC2s frequencies with significant differences between CBD-treated mice versus the placebo group (** p ≤ 0.02) as well as between normal WT and AD mice treated with placebo (** p ≤ 0.01). (d) Histograms from flow cytometric analysis revealed that CBD inhalation enhanced ACh expression by meningeal ILC2s significantly compared to the placebo treated group (* p ≤ 0.05). (e) UMAP analytical pattern demonstrated changes in the distribution and frequency of meningeal ILC2s in WT and 5xFAD mice treated with placebo/CBD.