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. 2024 Nov 1;25(21):11764. doi: 10.3390/ijms252111764

Figure 6.

Figure 6

Inhaled CBD shifts immune profile in the choroid plexus of mice with AD towards the normal status. (a,b) Flow cytometry analysis showed excessive accumulation of ILC2s in the choroid plexus (CP) of 5xFAD mice with AD treated with placebo compared to AD mice with CBD inhalation. Inhaled CBD reversed such alteration towards the normal status, reduced ILC2s in the CP, and increased meningeal ILC2s. (c) Quantification of ILC2s frequencies in the CP with significant differences between CBD-treated mice versus the placebo group (** p ≤ 0.02) as well as between normal WT and AD mice treated with placebo (** p ≤ 0.02). (d) Histograms from flow cytometric analysis revealed that CBD inhalation enhanced ACh expression by ILC2s in the CP compared to the placebo-treated group. (e) UMAP analytical pattern demonstrated changes in the distribution and frequency of ILC2s in the CP of WT and 5xFAD mice treated with placebo/CBD.